Overview
Tumour genomes carry the history of how a cancer arose. We call, filter and interpret somatic changes.
Salient features
- Somatic SNV and indel calling with filtering
- Signature extraction and attribution
- Clonal structure and heterogeneity
Analyses we offer
Somatic mutation analysis
Calls and filters tumour-specific mutations, and summarises them across cohorts.
Methods: maftools, strelka.
Mutational signature analysis
Extracts and assigns mutational signatures that point to underlying processes.
Methods: SigProfilerExtractor, deconstructSigs.
Tumor heterogeneity & clonal evolution
Reconstructs subclones and their evolution from bulk or single-cell data.
Methods: phylowgs, sciclone.
What you receive
- A written report with methods, parameters and interpretation
- Processed data tables and publication-quality figures
- Scripts and settings so every result can be reproduced
Not sure which analysis fits your data? Contact us and we will advise.