Overview
How the genome folds in three dimensions controls gene regulation. We build contact maps and call loops, domains and compartments.
Salient features
- Contact-matrix generation and normalisation
- TAD, loop and compartment calling
- Targeted 3C/4C interaction profiles
Analyses we offer
Hi-C analysis
Builds contact maps and calls loops, domains and compartments from Hi-C data.
Methods: cooler, juicer, HiC-Pro, nf-core hic.
4C-seq analysis
Profiles interactions of a chosen viewpoint with the rest of the genome.
Methods: peakC, pipe4C.
3C-seq analysis
Analyses chromosome conformation capture data for targeted interactions.
Methods: hicstuff, r3Cseq.
ChIA-PET analysis
Maps protein-mediated long-range chromatin interactions.
Methods: ChIA-PIPE, mango.
What you receive
- A written report with methods, parameters and interpretation
- Processed data tables and publication-quality figures
- Scripts and settings so every result can be reproduced
Not sure which analysis fits your data? Contact us and we will advise.